Proliferative Effects of Estradiol, Progesterone, and Two CB Congeners and Their Metabolites on Gray Seal (Halichoerus grypus) Uterine Myocytes in Vitro
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چکیده
منابع مشابه
Proliferative effects of estradiol, progesterone, and two CB congeners and their metabolites on gray seal (Halichoerus grypus) uterine myocytes in vitro.
Gray seal females living in the Baltic Sea have been found to exhibit a high prevalence of uterine leiomyomas. These animals are also known to accumulate lipid-soluble PCBs in their blubber. PCBs have documented endocrine-disrupting effects; to investigate whether the PCBs could be part of the genesis of uterine smooth muscle tumors in this species, gray seal myometrial cell cultures were expos...
متن کاملGRAY SEAL (Halichoerus grypus): Western North Atlantic Stock
STOCK DEFINITION AND GEOGRAPHIC RANGE The gray seal is found on both sides of the North Atlantic, with three major populations: eastern Canada, northwestern Europe and the Baltic Sea (Katona et al. 1993). The western North Atlantic population occurs from New England to Labrador and is centered in the Sable Island region of Nova Scotia (Mansfield 1966; Katona et al. 1993; Davies 1957; Lesage and...
متن کاملCan a gray seal (Halichoerus grypus) generalize call classes?
Past researchers have found that gray seals (Halichoerus grypus) are capable of classifying vocal signals by call type using a trained set, but were unable to generalize to novel exemplars (Shapiro, Slater, & Janik, 2004). Given the importance of auditory categorization in communication, it would be surprising if the animals were unable to generalize acoustically similar calls into classes. Her...
متن کاملHistology of uterine leiomyoma and occurrence in relation to reproductive activity in the Baltic gray seal (Halichoerus grypus).
A high prevalence of uterine leiomyoma has been reported in Baltic gray seals aged 15 years and above. Studies on Baltic seals during the 1970s revealed high tissue concentrations of the organochlorines bis(chlorophenyl)-1,1,1-trichloroethane (DDT) and polychlorinated biphenyls (PCBs), lowered reproduction rate, and pathologic changes. In the second half of the 1970s, decreases of PCB and DDT i...
متن کاملDirect evidence for gray seal (Halichoerus grypus) predation and scavenging on harbor porpoises (Phocoena phocoena)
THIBAUT BOUVEROUX, Observatoire pour la Conservation et l’Etude des Animaux et Milieux Marins (OCEAMM), 51 Rue du G en eral de Gaulle, F-59123 Zuydcoote, France; JEREMY J. KISZKA andMICHAEL R. HEITHAUS, Marine Sciences Program, Department of Biological Sciences, Florida International University, 3000 NE 151st Street, North Miami, Florida 33181, U.S.A.; THIERRY JAUNIAUX, Department of Veterinary...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2003
ISSN: 1096-0929
DOI: 10.1093/toxsci/kfg161